4D Flow MRI 를 이용한 in-vivo 유동 연구성과

4D Flow MRI 를 이용한 in-vivo 유동 연구성과를  정리해 보았습니다.
학회 발표상 3건, 논문 Editor’s Picks Magnetic Resonance in Medicine, SCI(e) 논문 10편, 국제 학회 발표 18건, 언론 홍보 24건, 새로운 4D Flow MRI 촬영 및 분석 기법, 4D Flow MRI 분석 SW 개발  등이 성과

 

Sci Rep. 2016 (4.25) Aug 26;6:32316. doi: 10.1038/srep32316.

수상

● Best Paper ICMRI 2017, valuation of Three-dimensional Flow Characteristics behind the Prosthetic Mechanical Valve under Subvalvular Pannus Formation; In-vitro 4D Flow MRI

● Editor’s Picks for the month of May, Magnetic Resonance in Medicine, Multi-VENC Acquisition of Four-Dimensional Phase Contrast MRI to Improve Precision of Velocity Field Measurement, Hojin Ha, et al., Magn Reson Med. 2015 Jun 8.

● 2016 Best scientific award The 4th International Congress on MRI and 21st Annual Scientific Meeting of KSMRM, 4D PC-MRI Quantification of the Hemodynamic Features in the Thoracic Aorta (oral)

● 2016 Certificate of Merit, Radiology Society of North America (RSNA), Hemodynamic Measurements using 4D PC-MRI: Quantification of Wall Shear Stress, Helicity and Turbulence of Blood Flow

●2015 Certificate of Merit Radiology Society of North America (RSNA) Prize2015 Certificate of Merit Radiology Society of North America (RSNA) PrizeHemodynamic Measurements using 4D PC-MRI: Quantification of Wall Shear Stress, Helicity and Turbulence of Blood Flow

 

유관과제

● 한-EU 연구자교류사업을 통한 네델란드 위트리히트 대학 연수 및 공동연구, Using 7T 4D Venc, development of quantification SW on brain-cardiac disease specific in-vivo blood flow and its application for diagnosis and treatment response (7T용 4D 자기공명유속영상을 이용한 심뇌혈관 질환의 in-vivo 유동 규명 및 혈관 진단 및 치료반응예측을 위한 정량화 SW개발), 한-EU 연구자교류사업, 기초연구사업

논문

1. Association between flow skewness and aortic dilatation in patients with aortic stenosis. Ha H, Koo HJ, Lee JG, Kim GB, Kweon J, Lee SJ, Kang JW, Lim TH, Kim DH, Song JM, Kang DH, Song JK, Kim YH, Kim N*, Yang DH. Int J Cardiovasc Imaging. 2017 Dec;33(12):1969-1978. doi: 10.1007/s10554-017-1196-x. Epub 2017 Jun 16. PMID: 28623496 (co-CA)
2. Four-dimensional flow MRI for evaluation of post-stenotic turbulent flow in a phantom: comparison with flowmeter and computational fluid dynamics. Kweon J, Yang DH, Kim GB, Kim N, Paek M, Stalder AF, Greiser A, Kim YH. Eur Radiol. 2016 Oct;26(10):3588-97. doi: 10.1007/s00330-015-4181-6.
3. The influence of the aortic valve angle on the hemodynamic features of the thoracic aorta. Ha H1, Kim GB2, Kweon J3, Lee SJ1,4, Kim YH3, Kim N5,6*, Yang DH6. Sci Rep. 2016 (4.25) Aug 26;6:32316. doi: 10.1038/srep32316.  (co-CA)
4. Hemodynamic Measurement Using Four-Dimensional Phase-Contrast MRI: Quantification of Hemodynamic Parameters and Clinical Applications. Ha H, Kim GB, Kweon J, Lee SJ, Kim YH, Lee DH, Yang DH, Kim N*. Korean J Radiol. 2016 Jul-Aug;17(4):445-62. doi: 10.3348/kjr.2016.17.4.445. Epub 2016 Jun 27. Review.
5. Turbulent Kinetic Energy Measurement Using Phase Contrast MRI for Estimating the Post-Stenotic Pressure Drop: In Vitro Validation and Clinical Application. Ha H, Kim GB, Kweon J, Huh HK, Lee SJ, Koo HJ, Kang JW, Lim TH, Kim DH, Kim YH, Kim N*, Yang DH. PLoS One. 2016 Mar 15;11(3):e0151540. doi: 10.1371/journal.pone.0151540. eCollection 2016. PMID: 26978529
6. Perfusion parameters as potential imaging biomarkers for the early prediction of radiotherapy response in a rat tumor model. Lee HY1, Kim N**, Goo JM, Chie EK, Song HJ., Diagn Interv Radiol. 2016 May-Jun;22(3):231-40. doi: 10.5152/dir.2015.15171. (Co-first, FA)
7. Estimation of Turbulent Kinetic Energy using 4D Phase-Contrast MRI: Effect of Scan Parameters and Target Vessel Size. Ha H, Hwang D, Kim GB, Kweon J, Lee SJ, Baek J, Kim YH, Kim N*, Yang DH. Magn Reson Imaging. 2016 Jul;34(6):715-723. doi: 10.1016/j.mri.2016.03.008. Epub 2016 Mar 8. PMID: 26968139 coCA
8. Post-stenotic plug-like jet with a vortex ring demonstrated by 4D flow MRI, Kim GB1, Ha H2, Kweon J1, Lee SJ3, Kim YH4, Yang DH5, Kim N*., Magn Reson Imaging. 2016 May;34(4):371-5. doi: 10.1016/j.mri.2015.11.010. PMID: 26657978
9. Multi-VENC Acquisition of Four-Dimensional Phase Contrast MRI to Improve Precision of Velocity Field Measurement, Hojin Ha, Guk Bae Kim, Jihoon Kweon, Young-Hak Kim, Namkug Kim, Dong Hyun Yang, and Sang Joon Lee, Magn Reson Med. 2016 May;75(5):1909-19. doi: 10.1002/mrm.25715. doi: 10.1002/mrm.25715. PMID: 26059014
10. Post-stenotic Recirculating Flow May Cause Hemodynamic Perforator Infarction, Bum Joon Kim,a Hojin Ha,b Hyung Kyu Huhb, Guk Bae Kim,c Jong S. Kim,a Namkug Kim,d,e Sang-Joon Lee,b Dong-Wha Kang,a Sun U. Kwon,a, J Stroke. 2015 Dec 17. doi: 10.5853/jos.2015.01445. , PMID: 26687122 (SCIe)
11. Stress Myocardial Perfusion CT in Patients Suspected of Having Coronary Artery Disease: Visual and Quantitative Analysis—Validation by Using Fractional Flow Reserve, Dong Hyun Yang, MD, PhD Young-Hak Kim, MD, PhD Jae-Hyung Roh, MD Joon-Won Kang, MD, PhD Dongjin Han, PhD Joonho Jung, MS Namkug Kim, PhD Jung Bok Lee, PhD Jung-Min Ahn, MD, PhD Jong-Young Lee, MD, PhD Duk-Woo Park, MD, PhD Soo-Jin Kang, MD, PhD Seung-Whan Lee, MD, PhD Cheol Whan Lee, MD, PhD Seong-Wook Park, MD, PhD Seung-Jung Park, MD, PhD Tae-Hwan Lim, MD, PhD, Radiology. 2015 Sep;276(3):715-23. doi: 10.1148/radiol.2015141126. Epub 2015 Apr 16. PMID: 25880262

학회 발표

1. Evaluation of three-dimensional flow characteristics behind the prosthetic mechanical valve under subvalvular pannus formation; in-vitro 4D flow MRI, Hyung Kyu Huh, Hojin Ha, Sang Joon Lee, Namkug Kim, Donghyun Yang, ISMRM 2017
2. Young Hoon Cho, MD, BeomHee Park, Ilsang Woo, Gaeun Lee and Joon Beom Seo,MDEvaluation of Three-dimensional Flow Characteristics behind the Prosthetic Mechanical Valve under Subvalvular Pannus Formation; In-vitro 4D Flow MRI, Hyungkyu Huh1 , Donghyun Yang2 , Namkug Kim, ICMRI & KSMRM 2017, March 23-25, 2017, Grand Hilton Hotel, Seoul, Korea (oral)
3. Evaluation of Three-dimensional Flow Characteristics Behind the Prosthetic Mechanical Valve Under Subvalvular Pannus Formation; In-vitro 4D Flow MRI Hyungkyu Huh1 , Donghyun Yang2 , Namkug Kim2, ICMRI & KSMRM 2017, March 23-25, 2017, Grand Hilton Hotel, Seoul, Korea (poster)
4. The influence of the aortic valve angle on the hemodynamic features of the thoracic aorta determined using 4D phase-contrast MR imaging Hojin Ha1, Guk Bae Kim2, Jihoon Kweon2, Sang Joon Lee1, Young-Hak Kim2, Namkug Kim2, Dong Hyun Yang2 1Pohang University of Science and Technology, 2Asan Medical Center, Korea KCR 2016, 2016.09.21-23, Coex, Seoul, Korea
5. Turbulent kinetic energy measurement using phase contrast MRI for estimating the post-stenotic pressure drop: in vitro validation and clinical application Hojin Ha1, Dong Hyun Yang2, Joon-Won Kang2, Young-Hak Kim2, Namkug Kim2, Tae-Hwan Lim2 1Pohang University of Science and Technology, 2Asan Medical Center, Korea. KCR 2016, 2016.09.21-23, Coex, Seoul, Korea
6. The 4D PC-MRI Quantification of the Hemodynamic Features in the Thoracic Aorta (oral), Hojin Ha1, Guk Bae Kim2, Jihoon Kweon3, Sang Joon Lee4, Young-Hak Kim3, Dong HyunYang6, Namkug Kim5, The 4th International Congress on Magnetic Resonance Imaging (ICMRI 2016) and 21st Annual Scientific Meeting of KSMRM, March 24-26, 2016, Grand Hilton Hotel, Seoul, Korea, Best oral presentation
7. Quantitative Measurement of Blood-Flow Pulsatility Dampening along Carotid Siphon with 4D Flow MRI of 3T and 7T MRI Namkug Kim1, Hojin Ha1, Gukbae Kim1, Deok Hee Lee1, Jjm Zwanenburg2, Lennart Geurts2, The 4th International Congress on Magnetic Resonance Imaging (ICMRI 2016) and 21st Annual Scientific Meeting of KSMRM, March 24-26, 2016, Grand Hilton Hotel, Seoul, Korea
8. The 4D PC-MRI Quantification of the Hemodynamic Features in the Thoracic Aorta (poster), Hojin Ha1, Guk Bae Kim2, Jihoon Kweon3, Sang Joon Lee4, Young-Hak Kim3, Dong Hyun Yang6, Namkug Kim5, The 4th International Congress on Magnetic Resonance Imaging (ICMRI 2016) and 21st Annual Scientific Meeting of KSMRM, March 24-26, 2016, Grand Hilton Hotel, Seoul, Korea
9. Hemodynamic Measurements using 4D PC-MRI: Quantification of Wall Shear Stress, Helicity and Turbulence of Blood Flow, H Ha, Pohang, AF KOREA, REPUBLIC OF; G Kim; J Kweon, PhD; H Koo, MD; Y Kim; N Kim, PhD; et al., Education Exhibits, RADIOLOGICAL SOCIETY OF NORTH AMERICA  2015, Nov 29- Dec 4, McCormick Plance, Chicago
10. Multi-VENC measurement of 4D phase contrast MRI for better blood flow measurement, Hojin Ha1, Guk Bae Kim2, Jihhoon Kweon2, Sang Joon Lee3, Young-Hak Kim2, Namkug Kim2, Dong Hyun Yang2, The 71th Korean Congress of Radiology and Annual Delegate Meeting of The Korean Society of Radiology, Sep 9 (Wed) – 12 (Sat), 2015 Coex, Seoul, Korea
11. Application of Particle Image Velocity for Confirming Abnormal Hemodynamic Features in the Suspicious Stroke Region Found in Clinical Imaging, H Ha, Pohang, AF KOREA, REPUBLIC OF; B Kim; G Kim; N Kim, PhD; D Kang; S Kwon (namkugkim@gmail.com), Education Exhibits, RADIOLOGICAL SOCIETY OF NORTH AMERICA  2015, Nov 29- Dec 4, McCormick Plance, Chicago
12. 4D flow MRI for evaluation of post-stenotic turbulent flow in phantom: comparison with 2D PC MRI and computational fluid dynamics, Jihoon Kweon, Dong Hyun Yang, Guk bae Kim, Namkug Kim, Young-Hak Kim, The 71th Korean Congress of Radiology and Annual Delegate Meeting of The Korean Society of Radiology, Sep 9 (Wed) – 12 (Sat), 2015 Coex, Seoul, Korea
13. Separated momentum of pulsatile stenotic flow found at post-stenotic region and postsystole phase, Guk bae Kim1, Hojin Ha2, Dong Hyun Yang, Sang Joon Lee2, Jihoon Kweon1, Young-Hak Kim1,Namkug Kim1, The 71th Korean Congress of Radiology and Annual Delegate Meeting of The Korean Society of Radiology, Sep 9 (Wed) – 12 (Sat), 2015 Coex, Seoul, Korea
14. Multi-Venc Measurement of Phase Contrast MRI for Improving Accuracy of Velocity Field, Ha, Hojin  Kim, Guk Bae  Kweon, Jihoon  Kim, Young-Hak  Kim, Namkug  Yang, Dong Hyun  Lee, Sang Joon, ISMRM 2014, 30 May-5 June 2015, Toronto, Ontario, Canada
15. Quantification of hemodynamic wall shear stress with non-fully developed flow using phase-contrast MRI in patients with aortic valve dysfunction, Hojin Ha1, Guk Bae Kim2, Jihoon Kweon3, Sang Joon Lee1, Young-Hak Kim3, Dong Hyun Yang5, Namkug Kim4, The 3rd ICMRI & The 20th KSMRM, March 27-28, 2015, Grand Hilton Seoul Hotel, Seoul, Korea
16. Multi-VENC Acquisition of 4D Phase Contrast MRI for Improving Accuracy of Velocity Field Measurement, Hojin Ha1, Guk Bae Kim2, Jihoon Kweon3, Young-Hak Kim3, Namkug Kim4, Dong Hyun Yang5and Sang Joon Lee1, The 3rd ICMRI & The 20th KSMRM, March 27-28, 2015, Grand Hilton Seoul Hotel, Seoul, Korea
17. 4D Flow MRI for Evaluation of Post-stenotic Turbulent Flow in Phantom: Comparison with 2D PC MRI and Computational Fluid Dynamics’, Jihoon Kweon1, Dong Hyun Yang2, Guk Bae Kim2, Namkug Kim2and Young-Hak Kim1, The 3rd ICMRI & The 20th KSMRM, March 27-28, 2015, Grand Hilton Seoul Hotel, Seoul, Korea
18. Four Dimentional Phase-Contrast MRI Observation in Pulsatile Flow of Stenotic Phantom: Separated Flow Momentum, Guk Bae Kim1, Hojin Ha2, Jihoon Kweon1, Dong Hyun Yang3, Sang Joon Lee2, Young Hak Kim4 and Namkuk Kim, The 3rd ICMRI & The 20th KSMRM, March 27-28, 2015, Grand Hilton Seoul Hotel, Seoul, Korea
19. Time-Dependent Wall Shear Stress Measurement in Middle Cerebral Artery (MCA) using Bi-Exponential Curve Fitting of Phase Contrast MR Angiography, N. Kim, S.K. Lee, M. Dunlap, MRP, C.M. Schirmer, C. David, K. Hreib, I.S. Choi, 19th Annual Meeting & Exhibition ISMRM 2011, Montreal, Quebec, Canada, May 7-13, 2011

특허

• QUANTIFICATION METHOD FOR MEDICAL IMAGE (의료영상의정량화방법) 2013.08.20 10-1521959 2015.05.14 Issued KOR
• QUANTIFICATION METHOD FOR MEDICAL IMAGE (의료영상의정량화방법) 2013.08.20 10-1521959 2015.05.14 Issued KOR
• QUANTIFICATION METHOD FOR MEDICAL IMAGE (의료영상의정량화방법) 2014.06.04 PTC PCT
• QUANTIFICATION METHOD FOR MEDICAL IMAGE (의료영상의정량화방법) 2016.02.22 Issued USA
• MRI 촬영 데이터 처리 방법(PROCESSING METHOD FOR MAGNETIC RESONANCE IMAGING DATA) 2015.08.13 Pending KOR
• Venc난류 운동 에너지 획득 장치 및 그 방법(TURBULENCE KINETIC ENERGY ACQUISITION APPARATUS AND METHOD THEREOF) 2015.09.01 Pending KOR
• 인체 내 장기모사 팬텀 PCT/KR2016/003396 2016.04.01 PCT PCT 김남국,김국배 UUCM PCTMethod for quantifying medical image 2016.02.22 Pending USA

언론 홍보

1. 3D 프린팅4D MRI로 대동맥 혈류 분석 성공, 문화일보, 2016년 09월 20일(火), http://www.munhwa.com/news/view.html?no=2016092001032121080001
2. 3D프린팅-4D MRI 접목 대동맥 혈류 방향속도 분석 성공, 메디컬투데이, 2016-09-20, http://www.mdtoday.co.kr/mdtoday/index.html?no=273309
3. 서울아산병원, 첨단 영상 진단으로 대동맥 혈류 흐름 잡아낸다, 이뉴스투데이, 2016.09.19, http://www.enewstoday.co.kr/news/articleView.html?idxno=603581
4. 서울아산병원포스텍 연구팀, ‘3D프린팅·4D MRI 접목’ 대동맥 혈류 방향·속도 첫 분석, 스포츠조선 라이프, 2016-09-19, http://sports.chosun.com/news/ntype.htm?id=201609200100134670009722&servicedate=20160919
5. 3D프린팅+4D MRI 접목 ‘대동맥 혈류’ 흐름 규명, 데일리메디, 2016-09-19, http://www.dailymedi.com/detail.php?number=810311&thread=22r02
6. ‘대동맥 혈류변화’ 첨단 영상장비로 분석, 서울신문, http://www.seoul.co.kr/news/newsView.php?id=20160919500125&wlog_tag3=naver
7. 3D프린터로 혈관 모형 만들고 4D MRI로 혈액흐름 분석해 심혈관병 예측법 개발, 한국경제, http://www.hankyung.com/news/app/newsview.php?aid=201609197866i
8. 서울아산병원, 3D프린팅으로 각종 심혈관 질환 예측 진단 가능, 파이낸션뉴스, http://www.fnnews.com/news/201609191426023389
9. “첨단 영상으로 대동맥 혈류흐름 분석”, 뉴스토마토, http://www.newstomato.com/ReadNews.aspx?no=690318
10. 3D프린팅-4D MRI 접목…대동맥 혈류 방향‧속도 분석, 데이리팜, http://www.dailypharm.com/News/216356
11. 회오리치는 ‘나쁜’ 혈류 분석 성공… 심혈관질환 진단에 도움, 헬스조선, http://health.chosun.com/site/data/html_dir/2016/09/19/2016091901661.html
12. MRI로 대동맥혈류 분석해 심질환 진단예측, 메디칼트리뷴, http://www.medical-tribune.co.kr/news/articleView.html?idxno=69203
13. 환자의 대동맥 혈류 방향와 속도 분석에 성공, 메디칼 옵져버, http://www.monews.co.kr/news/articleView.html?idxno=93633
14. 3D프린팅-4D MRI 접목해 대동맥 혈류 방향속도 첫 분석, 매일경제, http://news.mk.co.kr/newsRead.php?no=657710&year=2016
15. 영상진단 기술로 대동맥 혈류 흐름 잡아낸다, 의협신문, http://www.doctorsnews.co.kr/news/articleView.html?idxno=112638
16. 아산병원, 3D프린팅으로 ‘대동맥 혈류흐름’ 분석…4D MRI 접목, 뉴시스, http://www.newsis.com/ar_detail/view.html?ar_id=NISX20160919_0014394628&cID=10201&pID=10200
17. 첨단 영상 진단 기술로 대동맥 혈류 흐름 잡아낸다, 메디파나, http://medipana.com/news/news_viewer.asp?NewsNum=188336&MainKind=A&NewsKind=5&vCount=12&vKind=1
18. 대동맥 피의 흐름 포착…심혈관 질환 예측진단한다, 아시아경제, http://view.asiae.co.kr/news/view.htm?idxno=2016091911230789230
19. 3D 프린팅4D MRI 접목, 대동맥 혈류 흐름 잡다, 의학신문, http://www.bosa.co.kr/umap/sub.asp?news_pk=609146
20. 첨단 영상기술로 ‘대동맥 혈류’ 흐름 파악한다, 쿠키뉴스, http://www.kukinews.com/news/article.html?no=395318
21. 3D프린팅 기술 접목시켜 대동맥혈류이상 잡는다, 국민일보, http://news.kmib.co.kr/article/view.asp?arcid=0010936596&code=61171911&cp=nv
22. 첨단 영상 진단기술로 대동맥 혈류 흐름 잡아낸다, 이데일리, http://www.edaily.co.kr/news/NewsRead.edy?SCD=JG61&newsid=02227126612781760&DCD=A00706&OutLnkChk=Y
23. ‘대동맥 혈류변화’ 첨단 영상 진단 기술로 확인한다, 연합뉴스, http://www.yonhapnews.co.kr/bulletin/2016/09/19/0200000000AKR20160919066000017.HTML?input=1195m
24. 첨단 영상진단 기술로 대동맥 혈류 방향속도 분석, 라포르시안, http://www.rapportian.com/n_news/news/view.html?no=28624